{"metadata":{"accession":"PF04394","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007489","hierarchy":null,"name":{"name":"Protein of unknown function, DUF536","short":"DUF536"},"description":[{"text":"<p>This family aligns the C-terminal region from several bacterial proteins of unknown function that may be involved in a theta-type replication mechanism [[cite:PUB00019474],[cite:PUB00099934],[cite:PUB00099935]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00019474":{"PMID":8302939,"ISBN":null,"volume":"30","issue":"3","year":1993,"title":"Identification and characterization of a mobilization gene in the streptococcal plasmid, pVA380-1.","URL":null,"raw_pages":"296-302","medline_journal":"Plasmid","ISO_journal":"Plasmid","authors":["LeBlanc DJ","Chen YY","Lee LN."],"DOI_URL":"http://dx.doi.org/10.1006/plas.1993.1063"},"PUB00099935":{"PMID":32240216,"ISBN":null,"volume":"15","issue":"4","year":2020,"title":"Nucleotide sequence and analysis of pRC12 and pRC18, two theta-replicating plasmids harbored by Lactobacillus curvatus CRL 705.","URL":null,"raw_pages":"e0230857","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Teran LC","Cuozzo SA","Aristimuno Ficoseco MC","Fadda S","Chaillou S","Champomier-Verges MC","Zagorec M","Hebert EM","Raya RR."],"DOI_URL":null},"PUB00099934":{"PMID":21822904,"ISBN":null,"volume":"93","issue":"1","year":2012,"title":"Sequencing and analysis of three plasmids from Lactobacillus casei TISTR1341 and development of plasmid-derived Escherichia coli-L. casei shuttle vectors.","URL":null,"raw_pages":"261-72","medline_journal":"Appl Microbiol Biotechnol","ISO_journal":"Appl Microbiol Biotechnol","authors":["Panya M","Lulitanond V","Tangphatsornruang S","Namwat W","Wannasutta R","Suebwongsa N","Mayo B."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":398,"pathways":0,"proteins":398,"proteomes":318,"sets":0,"structural_models":{"alphafold":263},"structures":1,"taxa":534},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":112},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}