LptE (formerly known as RplB) is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported from its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptD appears to be anchored in the outer membrane, and LptE forms a complex with it. This part of the machinery complex is involved in the assembly of lipopolysaccharide in the outer leaflet of the outer membrane [[cite:PUB00053165]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Bacterial_outer_membrane","extract":"The bacterial outer membrane is found in gram-negative bacteria. Gram-negative bacteria form two lipid bilayers in their cell envelopes - an inner membrane (IM) that encapsulates the cytoplasm, and an outer membrane (OM) that encapsulates the periplasm.
","thumbnail":null}],"literature":{"PUB00053165":{"PMID":18424520,"ISBN":null,"volume":"190","issue":"13","year":2008,"title":"Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.","URL":null,"raw_pages":"4460-9","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Sperandeo P","Lau FK","Carpentieri A","De Castro C","Molinaro A","Deho G","Silhavy TJ","Polissi A."],"DOI_URL":"http://dx.doi.org/10.1128/JB.00270-08"}},"set_info":{"accession":"CL0342","name":"TolB_N"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":8831,"pathways":0,"proteins":8831,"proteomes":8765,"sets":1,"structural_models":{"alphafold":5850},"structures":39,"taxa":12339},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":281,"alignment:full":4336},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}