{"metadata":{"accession":"PF04379","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007474","hierarchy":null,"name":{"name":"ApaG domain","short":"DUF525"},"description":[{"text":"<p>The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity [[cite:PUB00009972],[cite:PUB00016988],[cite:PUB00018539],[cite:PUB00016989]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00009972":{"PMID":1779764,"ISBN":null,"volume":"5","issue":"11","year":1991,"title":"Magnesium transport in Salmonella typhimurium: the influence of new mutations conferring Co2+ resistance on the CorA Mg2+ transport system.","URL":null,"raw_pages":"2753-62","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Gibson MM","Bagga DA","Miller CG","Maguire ME."],"DOI_URL":"http://dx.doi.org/10.1111/j.1365-2958.1991.tb01984.x"},"PUB00016989":{"PMID":15213450,"ISBN":null,"volume":"29","issue":"3","year":2004,"title":"1H, 15N and 13C resonance assignments of the ApaG protein of the phytopathogen Xanthomonas axonopodis pv. citri.","URL":null,"raw_pages":"423-4","medline_journal":"J Biomol NMR","ISO_journal":"J. Biomol. NMR","authors":["Katsuyama AM","Cicero DO","Spisni A","Paci M","Farah CS","Pertinhez TA."],"DOI_URL":"http://dx.doi.org/10.1023/B:JNMR.0000032502.66997.25"},"PUB00018539":{"PMID":12522211,"ISBN":null,"volume":"278","issue":"12","year":2003,"title":"Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.","URL":null,"raw_pages":"10041-7","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Liu L","Rodriguez-Belmonte EM","Mazloum N","Xie B","Lee MY."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M208694200"},"PUB00016988":{"PMID":10945468,"ISBN":null,"volume":"67","issue":"1","year":2000,"title":"cDNA cloning and expression analysis of new members of the mammalian F-box protein family.","URL":null,"raw_pages":"40-7","medline_journal":"Genomics","ISO_journal":"Genomics","authors":["Ilyin GP","Rialland M","Pigeon C","Guguen-Guillouzo C."],"DOI_URL":"http://dx.doi.org/10.1006/geno.2000.6211"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":67,"interactions":0,"matches":11776,"pathways":0,"proteins":11744,"proteomes":9065,"sets":1,"structural_models":{"alphafold":8600},"structures":9,"taxa":15356},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":195,"alignment:full":6609},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5hdw","name":"ApaG Domain of FBxo3"}}}