{"metadata":{"accession":"PF04375","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007470","hierarchy":null,"name":{"name":"HemX, putative uroporphyrinogen-III C-methyltransferase","short":"HemX"},"description":[{"text":"<p>This is a family of bacterial putative uroporphyrinogen-III C-methyltransferase proteins. It forms one of the members of a complex of proteins involved in the biogenesis of the inner membrane in E.coli.  Uroporphorphyrin-III C-methyltransferase (HemX) is a single spanning inner membrane protein that regulates the activity of NAD(P)H:glutamyl-tRNA reductase (HemA) in the tetrapyrrole biosynthesis pathway [[cite:PUB00009969],[cite:PUB00054976]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00009969":{"PMID":3062586,"ISBN":null,"volume":"16","issue":"24","year":1988,"title":"Nucleotide sequence of the hemX gene, the third member of the Uro operon of Escherichia coli K12.","URL":null,"raw_pages":"11835","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Sasarman A","Echelard Y","Letowski J","Tardif D","Drolet M."],"DOI_URL":"http://dx.doi.org/10.1093/nar/16.24.11835"},"PUB00054976":{"PMID":16079137,"ISBN":null,"volume":"280","issue":"41","year":2005,"title":"Protein complexes of the Escherichia coli cell envelope.","URL":null,"raw_pages":"34409-19","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Stenberg F","Chovanec P","Maslen SL","Robinson CV","Ilag LL","von Heijne G","Daley DO."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M506479200"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":3875,"pathways":0,"proteins":3821,"proteomes":3792,"sets":0,"structural_models":{"alphafold":2341},"structures":0,"taxa":5052},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":1602},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}