{"metadata":{"accession":"PF04366","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007461","hierarchy":null,"name":{"name":"Las17-binding protein actin regulator","short":"Ysc84"},"description":[{"text":"<p>Ysc84 is a family of Las17-binding proteins found in metazoa. Together, Las17 and Ysc84 are essential for proper polymerisation of actin; Ysc84 is able to bind to and stabilise the actin dimer presented by Las17 and thereby promote polymerisation. An active actin cytoskeleton is necessary for adequate endocytosis.  ([pfam:PF00018]), or a FYVE zinc finger ([pfam:PF01363]).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00079455":{"PMID":19158382,"ISBN":null,"volume":"20","issue":"6","year":2009,"title":"The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.","URL":null,"raw_pages":"1618-28","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Robertson AS","Allwood EG","Smith AP","Gardiner FC","Costa R","Winder SJ","Ayscough KR."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E08-09-0982"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":156,"interactions":0,"matches":11738,"pathways":0,"proteins":11690,"proteomes":5737,"sets":0,"structural_models":{"alphafold":9138},"structures":1,"taxa":11239},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":234,"alignment:full":7945},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}