{"metadata":{"accession":"PF04356","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007451","hierarchy":null,"name":{"name":"Protein of unknown function (DUF489)","short":"DUF489"},"description":[{"text":"<p>Protein of unknown function, cotranscribed with purB in Escherichia coli, but with function unrelated to purine biosynthesis [[cite:PUB00009959]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00009959":{"PMID":8969519,"ISBN":null,"volume":"142 ( Pt 11)","issue":null,"year":1996,"title":"The purB gene of Escherichia coli K-12 is located in an operon.","URL":null,"raw_pages":"3219-30","medline_journal":"Microbiology","ISO_journal":"Microbiology (Reading, Engl.)","authors":["Green SM","Malik T","Giles IG","Drabble WT."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":2947,"pathways":0,"proteins":2941,"proteomes":2855,"sets":0,"structural_models":{"alphafold":1879},"structures":2,"taxa":3952},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":66,"alignment:full":1037},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1sdi","name":"1.65 A structure of Escherichia coli ycfC gene product"}}}