{"metadata":{"accession":"PF04343","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007438","hierarchy":null,"name":{"name":"Domain of unknown function DUF488","short":"DUF488"},"description":[{"text":"<p>This entry has been described to include subclades of DUF488 domains (namely DUF488-s, for DUF488-short subclade, DUF488-l for long subclade and DUF488-u for DUF488-standalone subclade) which all which contain the ancestral core of the domain. DUF488-s commonly pairs with the DUF488-l subclade on the genome. In the case of DUF488-l and DUF488-u, the core domain is followed by a single beta-strand that stacks at the C-terminus of the core beta-sheet and a multi-helical 'cap' [[cite:PUB00153826]]. Unlike the DUF488-s and DUF488-l subclades, DUF488-u is not found adjacent to other DUF488 subclades on the genome [[cite:PUB00153826]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00153826":{"PMID":36968430,"ISBN":null,"volume":"5","issue":"1","year":2023,"title":"New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts.","URL":null,"raw_pages":"lqad029","medline_journal":"NAR Genom Bioinform","ISO_journal":"NAR Genom Bioinform","authors":["Burroughs AM","Aravind L."],"DOI_URL":"https://doi.org/10.1093/nargab/lqad029"}},"set_info":{"accession":"CL0031","name":"Phosphatase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":25,"interactions":0,"matches":4652,"pathways":0,"proteins":4633,"proteomes":4007,"sets":1,"structural_models":{"alphafold":2903},"structures":0,"taxa":6608},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":205,"alignment:full":2521},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}