{"metadata":{"accession":"PF04328","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007423","hierarchy":null,"name":{"name":"Selenoprotein, putative","short":"Sel_put"},"description":[{"text":"<p>This entry includes a group of putative selenoproteins from Proteobacteria, Actinobacteria and Firmicutes. The invariant cysteine at the C terminus is encoded by a TGA Sec codon in some Epsilonproteobacteria, suggesting a redox activity for the protein[[cite:PUB00081206]]. Some members of this family have been suggested  to be required for pyruvate transport in diverse bacteria, along with a CstA-like transporter found adjacent in the genome (see Supplementary note 5 in [[cite:PUB00093610]].)</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00081206":{"PMID":26342139,"ISBN":null,"volume":"7","issue":"9","year":2015,"title":"Evolution of the Selenoproteome in Helicobacter pylori and Epsilonproteobacteria.","URL":null,"raw_pages":"2692-704","medline_journal":"Genome Biol Evol","ISO_journal":"Genome Biol Evol","authors":["Cravedi P","Mori G","Fischer F","Percudani R."],"DOI_URL":"http://dx.doi.org/10.1093/gbe/evv177"},"PUB00093610":{"PMID":29769716,"ISBN":null,"volume":"557","issue":"7706","year":2018,"title":"Mutant phenotypes for thousands of bacterial genes of unknown function.","URL":null,"raw_pages":"503-509","medline_journal":"Nature","ISO_journal":"Nature","authors":["Price MN","Wetmore KM","Waters RJ","Callaghan M","Ray J","Liu H","Kuehl JV","Melnyk RA","Lamson JS","Suh Y","Carlson HK","Esquivel Z","Sadeeshkumar H","Chakraborty R","Zane GM","Rubin BE","Wall JD","Visel A","Bristow J","Blow MJ","Arkin AP","Deutschbauer AM."],"DOI_URL":null},"PUB00070793":{"PMID":21348639,"ISBN":null,"volume":"15","issue":"7-8","year":2011,"title":"Ab initio modeling led annotation suggests nucleic acid binding function for many DUFs.","URL":null,"raw_pages":"431-8","medline_journal":"OMICS","ISO_journal":"OMICS","authors":["Rigden DJ."],"DOI_URL":"http://dx.doi.org/10.1089/omi.2010.0122"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":4241,"pathways":0,"proteins":4237,"proteomes":3897,"sets":0,"structural_models":{"alphafold":2587},"structures":0,"taxa":4993},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":57,"alignment:full":1628},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}