{"metadata":{"accession":"PF04326","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007421","hierarchy":null,"name":{"name":"Schlafen, AlbA_2","short":"SLFN_AlbA_2"},"description":[{"text":"<p>This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important in cell differentiation and defense against viruses [[cite:PUB00151569],[cite:PUB00151570]]. This domain is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence unique to these proteins that may form a dimer interface [[cite:PUB00151569]]. The AlbA_2 domain is RNA-binding and RNase region as it contains the highly conserved catalytic glutamic acid residues [[cite:PUB00151569]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151570":{"PMID":34571887,"ISBN":null,"volume":"10","issue":"9","year":2021,"title":"Schlafens: Emerging Proteins in Cancer Cell Biology. ","URL":null,"raw_pages":"2238","medline_journal":"Cells","ISO_journal":"Cells","authors":["Al-Marsoummi S","Vomhof-DeKrey EE","Basson MD."],"DOI_URL":null},"PUB00151569":{"PMID":31026779,"ISBN":null,"volume":"90","issue":null,"year":2019,"title":"Deciphering the three-domain architecture in schlafens and the structures and roles of human schlafen12 and serpinB12 in transcriptional regulation.","URL":null,"raw_pages":"59-76","medline_journal":"J Mol Graph Model","ISO_journal":"J Mol Graph Model","authors":["Chen J","Kuhn LA."],"DOI_URL":null}},"set_info":{"accession":"CL0441","name":"AlbA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":234,"interactions":0,"matches":12943,"pathways":0,"proteins":12925,"proteomes":7286,"sets":1,"structural_models":{"alphafold":8752},"structures":31,"taxa":13051},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":62,"alignment:full":7624},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}