{"metadata":{"accession":"PF04325","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007420","hierarchy":null,"name":{"name":"Protein of unknown function (DUF465)","short":"DUF465"},"description":[{"text":"<p>Family members are found in small bacterial proteins, and also in the heavy chains of fungal proteins that contain the domain kinesin, in which this region is located C-terminal of the motor domain ([pfam:PF00225]). It adopts a coiled-coil-like conformation [[cite:PUB00038888]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00038888":{"PMID":16231304,"ISBN":null,"volume":"61","issue":"4","year":2005,"title":"Solution structure of HP1242 from Helicobacter pylori.","URL":null,"raw_pages":"1111-3","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Kang SJ","Park SJ","Jung SJ","Lee BJ."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20654"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":9854,"pathways":0,"proteins":9854,"proteomes":5604,"sets":0,"structural_models":{"alphafold":6583},"structures":1,"taxa":7749},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":207,"alignment:full":5072},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}