{"metadata":{"accession":"PF04313","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007409","hierarchy":null,"name":{"name":"Type I restriction enzyme R protein N terminus (HSDR_N)","short":"HSDR_N"},"description":[{"text":"<p>This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA [[cite:PUB00019721]]. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA [[cite:PUB00019722]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019722":{"PMID":10449767,"ISBN":null,"volume":"96","issue":"17","year":1999,"title":"Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes.","URL":null,"raw_pages":"9757-62","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Makovets S","Doronina VA","Murray NE."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.96.17.9757"},"PUB00019721":{"PMID":11555298,"ISBN":null,"volume":"41","issue":"5","year":2001,"title":"Analysis of type I restriction modification systems in the Neisseriaceae: genetic organization and properties of the gene products.","URL":null,"raw_pages":"1199-210","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Piekarowicz A","Klyz A","Kwiatek A","Stein DC."],"DOI_URL":"http://dx.doi.org/10.1046/j.1365-2958.2001.02587.x"}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":90,"interactions":0,"matches":14727,"pathways":0,"proteins":14720,"proteomes":9564,"sets":1,"structural_models":{"alphafold":9590},"structures":11,"taxa":15110},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":74,"alignment:full":7768},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}