{"metadata":{"accession":"PF04306","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007403","hierarchy":null,"name":{"name":"Protein of unknown function (DUF456)","short":"DUF456"},"description":[{"text":"<p>This family is a putative membrane protein that contains glycine zipper motifs [[cite:PUB00055608]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00055608":{"PMID":16179394,"ISBN":null,"volume":"102","issue":"40","year":2005,"title":"Transmembrane glycine zippers: physiological and pathological roles in membrane proteins.","URL":null,"raw_pages":"14278-83","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Kim S","Jeon TJ","Oberai A","Yang D","Schmidt JJ","Bowie JU."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0501234102"}},"set_info":{"accession":"CL0500","name":"Glycine-zipper"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":5579,"pathways":0,"proteins":5579,"proteomes":5526,"sets":1,"structural_models":{"alphafold":3440},"structures":0,"taxa":7686},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":139,"alignment:full":2778},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}