Bacterial protein of unknown function. One family member ([swissprot:Q97LI1]) is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA). Another family member YeaH is predicted to be part of a conserved signalling pathway with the kinase YeaG and the SpoVR protein YcgB. The pathway may be involved in nitrogen metabolism (see Supplementary note 5 in [[cite:PUB00093610]].)
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00093610":{"PMID":29769716,"ISBN":null,"volume":"557","issue":"7706","year":2018,"title":"Mutant phenotypes for thousands of bacterial genes of unknown function.","URL":null,"raw_pages":"503-509","medline_journal":"Nature","ISO_journal":"Nature","authors":["Price MN","Wetmore KM","Waters RJ","Callaghan M","Ray J","Liu H","Kuehl JV","Melnyk RA","Lamson JS","Suh Y","Carlson HK","Esquivel Z","Sadeeshkumar H","Chakraborty R","Zane GM","Rubin BE","Wall JD","Visel A","Bristow J","Blow MJ","Arkin AP","Deutschbauer AM."],"DOI_URL":null}},"set_info":{"accession":"CL0128","name":"vWA-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":7057,"pathways":0,"proteins":5552,"proteomes":5312,"sets":1,"structural_models":{"alphafold":3617},"structures":0,"taxa":7469},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":78,"alignment:full":3292},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}