{"metadata":{"accession":"PF04224","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007339","hierarchy":null,"name":{"name":"Protein of unknown function, DUF417","short":"DUF417"},"description":[{"text":"<p>This family of uncharacterised integral membrane proteins appears to be restricted to proteobacteria. These proteins are related to the DoxX family [pfam:PF07681]. Members of this family form a confident homodimeric structure, for example UniProtKB:A0A4R5FQM0 iPTM=0.94.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0131","name":"DoxD-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":2090,"pathways":0,"proteins":1971,"proteomes":1536,"sets":1,"structural_models":{"alphafold":1271},"structures":0,"taxa":2351},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":747},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}