{"metadata":{"accession":"PF04217","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007334","hierarchy":null,"name":{"name":"Protein of unknown function, DUF412","short":"DUF412"},"description":[{"text":"<p>This family consists of bacterial proteins, including yfbV  from E. coli. YfbV is a membrane protein involved in  insulating the chromosome from the TerR macrodomain [[cite:PUB00104115]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00104115":{"PMID":22532809,"ISBN":null,"volume":"8","issue":"4","year":2012,"title":"Long-range chromosome organization in E. coli: a site-specific system isolates the Ter macrodomain.","URL":null,"raw_pages":"e1002672","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet","authors":["Thiel A","Valens M","Vallet-Gely I","Espeli O","Boccard F."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":1295,"pathways":0,"proteins":1295,"proteomes":1250,"sets":0,"structural_models":{"alphafold":852},"structures":0,"taxa":1757},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":392},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}