{"metadata":{"accession":"PF04190","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007317","hierarchy":null,"name":{"name":"Golgi to ER traffic protein 4","short":"GET4"},"description":[{"text":"<p>In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane [[cite:PUB00092561],[cite:PUB00092562]]. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation [[cite:PUB00092560],[cite:PUB00086005],[cite:PUB00086007],[cite:PUB00086008]]. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane [[cite:PUB00092560],[cite:PUB00086008],[cite:PUB00092563]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086008":{"PMID":28104892,"ISBN":null,"volume":"355","issue":"6322","year":2017,"title":"Mechanistic basis for a molecular triage reaction.","URL":null,"raw_pages":"298-302","medline_journal":"Science","ISO_journal":"Science","authors":["Shao S","Rodrigo-Brenni MC","Kivlen MH","Hegde RS."],"DOI_URL":"https://doi.org/10.1126/science.aah6130"},"PUB00086005":{"PMID":21636303,"ISBN":null,"volume":"42","issue":"6","year":2011,"title":"A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.","URL":null,"raw_pages":"758-70","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Wang Q","Liu Y","Soetandyo N","Baek K","Hegde R","Ye Y."],"DOI_URL":"https://doi.org/10.1016/j.molcel.2011.05.010"},"PUB00092563":{"PMID":25535373,"ISBN":null,"volume":"112","issue":"1","year":2015,"title":"Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.","URL":null,"raw_pages":"106-11","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Mock JY","Chartron JW","Zaslaver M","Xu Y","Ye Y","Clemons WM Jr."],"DOI_URL":"https://doi.org/10.1073/pnas.1402745112"},"PUB00092560":{"PMID":20676083,"ISBN":null,"volume":"466","issue":"7310","year":2010,"title":"A ribosome-associating factor chaperones tail-anchored membrane proteins.","URL":null,"raw_pages":"1120-4","medline_journal":"Nature","ISO_journal":"Nature","authors":["Mariappan M","Li X","Stefanovic S","Sharma A","Mateja A","Keenan RJ","Hegde RS."],"DOI_URL":"https://doi.org/10.1038/nature09296"},"PUB00092562":{"PMID":24727835,"ISBN":null,"volume":"21","issue":"5","year":2014,"title":"Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.","URL":null,"raw_pages":"437-42","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Gristick HB","Rao M","Chartron JW","Rome ME","Shan SO","Clemons WM Jr."],"DOI_URL":"https://doi.org/10.1038/nsmb.2813"},"PUB00092561":{"PMID":22190685,"ISBN":null,"volume":"287","issue":"7","year":2012,"title":"Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.","URL":null,"raw_pages":"4783-9","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Chang YW","Lin TW","Li YC","Huang YS","Sun YJ","Hsiao CD."],"DOI_URL":"https://doi.org/10.1074/jbc.M111.318329"},"PUB00086007":{"PMID":21743475,"ISBN":null,"volume":"475","issue":"7356","year":2011,"title":"Protein targeting and degradation are coupled for elimination of mislocalized proteins.","URL":null,"raw_pages":"394-7","medline_journal":"Nature","ISO_journal":"Nature","authors":["Hessa T","Sharma A","Mariappan M","Eshleman HD","Gutierrez E","Hegde RS."],"DOI_URL":"https://doi.org/10.1038/nature10181"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":66,"interactions":0,"matches":4204,"pathways":0,"proteins":4116,"proteomes":3267,"sets":1,"structural_models":{"alphafold":3516},"structures":11,"taxa":8653},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":130,"alignment:full":3233},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6au8","name":"1.8 angstrom crystal structure of the human Bag6-NLS & TRC35 complex"}}}