{"metadata":{"accession":"PF04187","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007314","hierarchy":null,"name":{"name":"Haem-binding uptake, Tiki superfamily, ChaN","short":"Cofac_haem_bdg"},"description":[{"text":"<p>This is a family of putative bacterial lipoproteins necessary for the uptake of haem-iron.  The structure of UniProtKB:Q0PBW2, PDB:2g5g, comprises a large parallel beta-sheet with flanking alpha-helices and a smaller domain consisting of alpha-helices. Two cofacial haem groups (~3.5 Angstom apart with an inter-iron distance of 4.4 Angstrom) bind in a pocket formed by a dimer of two ChaN monomers [[cite:PUB00075535],[cite:PUB00040938]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075535":{"PMID":23868957,"ISBN":null,"volume":"29","issue":"19","year":2013,"title":"Tiki, at the head of a new superfamily of enzymes.","URL":null,"raw_pages":"2371-4","medline_journal":"Bioinformatics","ISO_journal":"Bioinformatics","authors":["Sanchez-Pulido L","Ponting CP."],"DOI_URL":"http://dx.doi.org/10.1093/bioinformatics/btt412"},"PUB00040938":{"PMID":16950397,"ISBN":null,"volume":"362","issue":"5","year":2006,"title":"Cofacial heme binding is linked to dimerization by a bacterial heme transport protein.","URL":null,"raw_pages":"1108-19","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Chan AC","Lelj-Garolla B","I Rosell F","Pedersen KA","Mauk AG","Murphy ME."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2006.08.001"}},"set_info":{"accession":"CL0572","name":"TIKI"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":47,"interactions":0,"matches":4567,"pathways":0,"proteins":4545,"proteomes":3958,"sets":1,"structural_models":{"alphafold":3078},"structures":1,"taxa":6774},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":144,"alignment:full":2448},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2g5g","name":"Cofacial heme binding to ChaN of Campylobacter jejuni"}}}