{"metadata":{"accession":"PF04075","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004378","hierarchy":null,"name":{"name":"F420H(2)-dependent quinone reductase","short":"F420H2_quin_red"},"description":[{"text":"<p>This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterised as a deazaflavin-dependent nitroreductase [[cite:PUB00054201],[cite:PUB00054202]]. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection [[cite:PUB00077109]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00077109":{"PMID":23240649,"ISBN":null,"volume":"87","issue":"4","year":2013,"title":"A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.","URL":null,"raw_pages":"744-55","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Gurumurthy M","Rao M","Mukherjee T","Rao SP","Boshoff HI","Dick T","Barry CE 3rd","Manjunatha UH."],"DOI_URL":"http://dx.doi.org/10.1111/mmi.12127"},"PUB00054201":{"PMID":16387854,"ISBN":null,"volume":"103","issue":"2","year":2006,"title":"Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.","URL":null,"raw_pages":"431-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Manjunatha UH","Boshoff H","Dowd CS","Zhang L","Albert TJ","Norton JE","Daniels L","Dick T","Pang SS","Barry CE 3rd."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0508392103"},"PUB00054202":{"PMID":19039139,"ISBN":null,"volume":"322","issue":"5906","year":2008,"title":"PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.","URL":null,"raw_pages":"1392-5","medline_journal":"Science","ISO_journal":"Science","authors":["Singh R","Manjunatha U","Boshoff HI","Ha YH","Niyomrattanakit P","Ledwidge R","Dowd CS","Lee IY","Kim P","Zhang L","Kang S","Keller TH","Jiricek J","Barry CE 3rd."],"DOI_URL":"http://dx.doi.org/10.1126/science.1164571"}},"set_info":{"accession":"CL0336","name":"FMN-binding"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":77,"interactions":0,"matches":16750,"pathways":0,"proteins":16735,"proteomes":3114,"sets":1,"structural_models":{"alphafold":9873},"structures":12,"taxa":3942},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":7431},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3r5w","name":"Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420"}}}