This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site [[cite:PUB00013034]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00013034":{"PMID":12234937,"ISBN":null,"volume":"21","issue":"18","year":2002,"title":"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.","URL":null,"raw_pages":"4978-88","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Will CL","Urlaub H","Achsel T","Gentzel M","Wilm M","Luhrmann R."],"DOI_URL":"http://dx.doi.org/10.1093/emboj/cdf480"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":60,"interactions":0,"matches":4397,"pathways":0,"proteins":4347,"proteomes":3033,"sets":0,"structural_models":{"alphafold":3682},"structures":57,"taxa":8016},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":68,"alignment:full":3314},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}