{"metadata":{"accession":"PF04032","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007175","hierarchy":null,"name":{"name":"RNAse P Rpr2/Rpp21/SNM1 subunit domain","short":"Rpr2"},"description":[{"text":"<p>This family contains a ribonuclease P subunit of humans and yeast.  Other members of the family include the probable archaeal homologues. This family includes SNM1 [[cite:PUB00017140]].  It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically [[cite:PUB00017140]]. This subunit possibly binds the precursor tRNA [[cite:PUB00010581]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00050258":{"PMID":18929577,"ISBN":null,"volume":"384","issue":"3","year":2008,"title":"Structure of an archaeal homolog of the human protein complex Rpp21-Rpp29 that is a key core component for the assembly of active ribonuclease P.","URL":null,"raw_pages":"652-62","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Honda T","Kakuta Y","Kimura K","Saho J","Kimura M."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2008.09.056"},"PUB00017140":{"PMID":10523674,"ISBN":null,"volume":"19","issue":"11","year":1999,"title":"Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation.","URL":null,"raw_pages":"7857-69","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Cai T","Reilly TR","Cerio M","Schmitt ME."],"DOI_URL":"http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=10523674"},"PUB00010581":{"PMID":11497433,"ISBN":null,"volume":"7","issue":"8","year":2001,"title":"Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P.","URL":null,"raw_pages":"1153-64","medline_journal":"RNA","ISO_journal":"RNA","authors":["Jarrous N","Reiner R","Wesolowski D","Mann H","Guerrier-Takada C","Altman S."],"DOI_URL":"http://dx.doi.org/10.1017/S1355838201010469"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":63,"interactions":0,"matches":4495,"pathways":0,"proteins":4495,"proteomes":3138,"sets":1,"structural_models":{"alphafold":3875},"structures":13,"taxa":8020},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":251,"alignment:full":3232},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1x0t","name":"Crystal structure of ribonuclease P protein Ph1601p from Pyrococcus horikoshii OT3"}}}