{"metadata":{"accession":"PF04025","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007169","hierarchy":null,"name":{"name":"Extracellular matrix regulatory protein A-like","short":"RemA-like"},"description":[{"text":"<p>This family of mostly uncharacterised proteins includes the extracellular matrix regulatory protein A (RemA) from Bacillus subtilis. RemA is required for biosynthesis of the extracellular matrix and biofilm formation [[cite:PUB00089811],[cite:PUB00100525]]. It binds to DNA at multiple sites upstream of the promoters of the operons eps and tapA-sipW-tasA, which are required for the synthesis of the extracellular matrix components, extracellular polysaccharide and TasA amyloid proteins. SinR negatively regulates eps operon expression by occluding RemA binding [[cite:PUB00089811]]. Structure of RemA homologue from Geobacillus thermodenitrificans revealed that it forms an unique octameric ring with the potential to form a 16-meric superstructure and suggests that RemA can wrap DNA around its ring-like structure [[cite:PUB00100525]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00089811":{"PMID":23646920,"ISBN":null,"volume":"88","issue":"5","year":2013,"title":"RemA is a DNA-binding protein that activates biofilm matrix gene expression in Bacillus subtilis.","URL":null,"raw_pages":"984-97","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Winkelman JT","Bree AC","Bate AR","Eichenberger P","Gourse RL","Kearns DB."],"DOI_URL":"https://doi.org/10.1111/mmi.12235"},"PUB00100525":{"PMID":34588455,"ISBN":null,"volume":"12","issue":"1","year":2021,"title":"Structural and functional characterization of the bacterial biofilm activator RemA.","URL":null,"raw_pages":"5707","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Hoffmann T","Mrusek D","Bedrunka P","Burchert F","Mais CN","Kearns DB","Altegoer F","Bremer E","Bange G."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":3892,"pathways":0,"proteins":3892,"proteomes":2354,"sets":0,"structural_models":{"alphafold":2684},"structures":3,"taxa":4062},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":69,"alignment:full":2342},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7p1w","name":"Crystal structure of a R51 R53 double mutant of the DNA-binding protein RemA from Geobacillus thermodenitrificans"}}}