{"metadata":{"accession":"PF03995","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Peptidase inhibitor family I36","short":"Inhibitor_I36"},"description":[{"text":"<p>This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C ([swissprot:Q9ADK5]) and SCO3675 ([swissprot:Q9X8V7]) also have probable beta-propellers at their C-termini. This family includes [swissprot:P01077] a known peptidase inhibitor of known structure. This protein has a crystallin like fold [pfam:PF00030] and is distantly related by sequence.  It is not known whether other members of this family are peptidase inhibitors.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Protease_inhibitor_(biology)","extract":"<p>In biology and biochemistry, <b>protease inhibitors</b>, or <b>antiproteases</b>, are molecules that inhibit the function of proteases. Many naturally occurring protease inhibitors are proteins.</p>","thumbnail":null}],"literature":{"PUB00014341":{"PMID":9735297,"ISBN":null,"volume":"282","issue":"2","year":1998,"title":"NMR structure of the Streptomyces metalloproteinase inhibitor, SMPI, isolated from Streptomyces nigrescens TK-23: another example of an ancestral beta gamma-crystallin precursor structure.","URL":null,"raw_pages":"421-33","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Ohno A","Tate S","Seeram SS","Hiraga K","Swindells MB","Oda K","Kainosho M."],"DOI_URL":"http://dx.doi.org/10.1006/jmbi.1998.2022"},"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"}},"set_info":{"accession":"CL0333","name":"gCrystallin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":91,"interactions":0,"matches":5220,"pathways":0,"proteins":5144,"proteomes":1963,"sets":1,"structural_models":{"alphafold":2664},"structures":8,"taxa":2813},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":2326},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3i9h","name":"Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii"}}}