This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":23114,"pathways":0,"proteins":6957,"proteomes":6539,"sets":0,"structural_models":{"alphafold":4199},"structures":0,"taxa":8240},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":424,"alignment:full":11060},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}