This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593 ([swissprot:P25357]). This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis ([[cite:PUB00019472]]). The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the [pfam:PF07501] domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells [[cite:PUB00075582]]. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5 [[cite:PUB00137668]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00075582":{"PMID":19799629,"ISBN":null,"volume":"58","issue":"1","year":2010,"title":"Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling.","URL":null,"raw_pages":"39-50","medline_journal":"FEMS Immunol Med Microbiol","ISO_journal":"FEMS Immunol. Med. Microbiol.","authors":["Kana BD","Mizrahi V."],"DOI_URL":"http://dx.doi.org/10.1111/j.1574-695X.2009.00606.x"},"PUB00019472":{"PMID":11711434,"ISBN":null,"volume":"15","issue":"22","year":2001,"title":"The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.","URL":null,"raw_pages":"2991-3004","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Pijnappel WW","Schaft D","Roguev A","Shevchenko A","Tekotte H","Wilm M","Rigaut G","Seraphin B","Aasland R","Stewart AF."],"DOI_URL":"http://dx.doi.org/10.1101/gad.207401"},"PUB00137668":{"PMID":26549874,"ISBN":null,"volume":"1860","issue":"2","year":2016,"title":"The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains.","URL":null,"raw_pages":"445-51","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim Biophys Acta","authors":["Ruggiero A","Squeglia F","Romano M","Vitagliano L","De Simone A","Berisio R."],"DOI_URL":null},"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"}},"set_info":{"accession":"CL0072","name":"Ubiquitin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":12547,"pathways":0,"proteins":4937,"proteomes":4394,"sets":1,"structural_models":{"alphafold":3055},"structures":1,"taxa":5839},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":286,"alignment:full":6483},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}