This repeat is found as seven tandem copies in carbohydrate-binding proteins, including Fucose-binding Lectin from Photorhabdus laumondii ([swissprot:Q7N8J0]) and similar fungal and bacterial proteins. It is composed of beta-strands and forms a seven-bladed beta-propeller structure [[cite:PUB00100843],[cite:PUB00100844]]. It is found in association with BNR repeats, which also form a beta-propeller.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"},"PUB00100843":{"PMID":27758853,"ISBN":null,"volume":"291","issue":"48","year":2016,"title":"A Novel Fucose-binding Lectin from Photorhabdus luminescens (PLL) with an Unusual Heptabladed β-Propeller Tetrameric Structure.","URL":null,"raw_pages":"25032-25049","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Kumar A","Sykorova P","Demo G","Dobes P","Hyrsl P","Wimmerova M."],"DOI_URL":null},"PUB00100844":{"PMID":33765407,"ISBN":null,"volume":"29","issue":"9","year":2021,"title":"Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions.","URL":null,"raw_pages":"1003-1013.e4","medline_journal":"Structure","ISO_journal":"Structure","authors":["Gajdos L","Blakeley MP","Kumar A","Wimmerova M","Haertlein M","Forsyth VT","Imberty A","Devos JM."],"DOI_URL":null}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":53,"interactions":0,"matches":538,"pathways":0,"proteins":175,"proteomes":134,"sets":1,"structural_models":{"alphafold":106},"structures":0,"taxa":352},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":20,"alignment:full":207},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}