{"metadata":{"accession":"PF03966","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005651","hierarchy":null,"name":{"name":"Trm112p-like protein","short":"Trm112p"},"description":[{"text":"<p>The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length.  The C terminus contains the strongest conservation.  Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [[cite:PUB00020491]]. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast [[cite:PUB00041889]]. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [[cite:PUB00041889]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00020491":{"PMID":15899842,"ISBN":null,"volume":"25","issue":"11","year":2005,"title":"Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA.","URL":null,"raw_pages":"4359-70","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Purushothaman SK","Bujnicki JM","Grosjean H","Lapeyre B."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.25.11.4359-4370.2005"},"PUB00041889":{"PMID":17008308,"ISBN":null,"volume":"281","issue":"47","year":2006,"title":"The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.","URL":null,"raw_pages":"36140-8","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Heurgue-Hamard V","Graille M","Scrima N","Ulryck N","Champ S","van Tilbeurgh H","Buckingham RH."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M608571200"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":79,"interactions":0,"matches":15168,"pathways":0,"proteins":15167,"proteomes":13041,"sets":1,"structural_models":{"alphafold":10889},"structures":41,"taxa":22264},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":69,"alignment:full":8446},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6h2u","name":"Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 1.6A resolution"}}}