This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans [[cite:PUB00066692]]. Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria [[cite:PUB00066693]]. This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true. The E. coli protein, YgfY also acts as the antitoxin to the membrane-bound toxin family Cpta, [pfam:PF13166], whose E. coli member YgfX, expressed from the same operon as YgfY [[cite:PUB00075551]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Succinate_dehydrogenase_complex_subunit_C","extract":"Succinate dehydrogenase complex subunit C, also known as succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is a protein that in humans is encoded by the SDHC gene. This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with pheochromocytomas and paragangliomas. Alternatively spliced transcript variants have been described.
","thumbnail":null}],"literature":{"PUB00066692":{"PMID":19628817,"ISBN":null,"volume":"325","issue":"5944","year":2009,"title":"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.","URL":null,"raw_pages":"1139-42","medline_journal":"Science","ISO_journal":"Science","authors":["Hao HX","Khalimonchuk O","Schraders M","Dephoure N","Bayley JP","Kunst H","Devilee P","Cremers CW","Schiffman JD","Bentz BG","Gygi SP","Winge DR","Kremer H","Rutter J."],"DOI_URL":"http://dx.doi.org/10.1126/science.1175689"},"PUB00075551":{"PMID":22239607,"ISBN":null,"volume":"328","issue":"2","year":2012,"title":"A novel membrane-bound toxin for cell division, CptA (YgfX), inhibits polymerization of cytoskeleton proteins, FtsZ and MreB, in Escherichia coli.","URL":null,"raw_pages":"174-81","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol. Lett.","authors":["Masuda H","Tan Q","Awano N","Yamaguchi Y","Inouye M."],"DOI_URL":"http://dx.doi.org/10.1111/j.1574-6968.2012.02496.x"},"PUB00152207":{"PMID":22985599,"ISBN":null,"volume":"1827","issue":"5","year":2013,"title":"Prokaryotic assembly factors for the attachment of flavin to complex II.","URL":null,"raw_pages":"637-47","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim Biophys Acta","authors":["McNeil MB","Fineran PC."],"DOI_URL":"https://doi.org/10.1016/j.bbabio.2012.09.003"},"PUB00066693":{"PMID":22474332,"ISBN":null,"volume":"287","issue":"22","year":2012,"title":"SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria.","URL":null,"raw_pages":"18418-28","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["McNeil MB","Clulow JS","Wilf NM","Salmond GP","Fineran PC."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M111.293803"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":66,"interactions":0,"matches":10656,"pathways":0,"proteins":10651,"proteomes":9808,"sets":0,"structural_models":{"alphafold":7861},"structures":9,"taxa":17438},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":207,"alignment:full":6159},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1x6i","name":"Crystal structure of ygfY from Escherichia coli"}}}