{"metadata":{"accession":"PF03928","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005624","hierarchy":null,"name":{"name":"Haem degrading protein HbpS-like","short":"HbpS-like"},"description":[{"text":"<p>This entry includes haem degrading protein HbpS from Streptomyces reticuli (swiss:Q9RIM2) and and GlcG from Escherichia coli [[cite:PUB00007282]]. HbpS is up-regulated in response to haemin- and peroxide-based oxidative stress. It interacts with the SenS/SenR two-component signal transduction system. Iron binds to surface-exposed lysine residues of an octomeric assembly of the protein [[cite:PUB00052019]]. The structure of GlcG is composed of an alpha-beta(2)-alpha(3)-beta(2)-alpha fold, similar to the Roadblock/LC7 domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00052019":{"PMID":19244623,"ISBN":null,"volume":"386","issue":"4","year":2009,"title":"The oligomeric assembly of the novel haem-degrading protein HbpS is essential for interaction with its cognate two-component sensor kinase.","URL":null,"raw_pages":"1108-22","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Ortiz de Orue Lucana D","Bogel G","Zou P","Groves MR."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2009.01.017"},"PUB00007282":{"PMID":8606183,"ISBN":null,"volume":"178","issue":"7","year":1996,"title":"glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein.","URL":null,"raw_pages":"2051-9","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Pellicer MT","Badia J","Aguilar J","Baldoma L."],"DOI_URL":"http://jb.asm.org/cgi/content/abstract/178/7/2051"}},"set_info":{"accession":"CL0161","name":"GAF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":65,"interactions":0,"matches":17413,"pathways":0,"proteins":17179,"proteomes":9798,"sets":1,"structural_models":{"alphafold":10836},"structures":10,"taxa":14541},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":387,"alignment:full":8955},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9jth","name":"Crystal structure of NahX from Pseudomonas sp. MC1"}}}