{"metadata":{"accession":"PF03860","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005560","hierarchy":null,"name":{"name":"Copper storage protein","short":"Csp"},"description":[{"text":"<p>This domain is found in a number of copper storage proteins. It contains a repeat of highly conserved cysteines. The cysteines mostly follow a C-X(2)-C-X(3)-C-X(2)-C-X(3) pattern, though they often appear at other positions in the repeat as well [[cite:PUB00016669]]. These residues are involved in copper binding. This domain folds into a four helical up-and-down bundle [[cite:PUB00161196],[cite:PUB00161197]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"},"PUB00161196":{"PMID":31111982,"ISBN":null,"volume":"25","issue":"45","year":2019,"title":"A Histidine Residue and a Tetranuclear Cuprous-thiolate Cluster Dominate the Copper Loading Landscape of a Copper Storage Protein from Streptomyces lividans.","URL":null,"raw_pages":"10678-10688","medline_journal":"Chemistry","ISO_journal":"Chemistry","authors":["Straw ML","Hough MA","Wilson MT","Worrall JAR."],"DOI_URL":"https://doi.org/10.1002/chem.201901411"},"PUB00161197":{"PMID":27991525,"ISBN":null,"volume":"6","issue":null,"year":2016,"title":"Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity.","URL":null,"raw_pages":"39065","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Vita N","Landolfi G","Basle A","Platsaki S","Lee J","Waldron KJ","Dennison C."],"DOI_URL":"https://doi.org/10.1038/srep39065"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":6459,"pathways":0,"proteins":6459,"proteomes":4703,"sets":0,"structural_models":{"alphafold":3965},"structures":28,"taxa":6934},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":3055},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5fig","name":"APO-CSP3 (COPPER STORAGE PROTEIN 3) FROM BACILLUS SUBTILIS"}}}