{"metadata":{"accession":"PF03777","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005528","hierarchy":null,"name":{"name":"ChpA-C","short":"ChpA-C"},"description":[{"text":"<p>Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge. This domain is found in chaplins ChpA-C (coelicolor hydrophobic aerial) proteins. ChpA-C contain a canonical C-terminal sortase signal, which is recognized by sortase enzymes that covalently couple their substrates to the peptidoglycan present in the cell wall. Indeed, direct evidence for sortase-mediated coupling of ChpC has been demonstrated, and it is expected that ChpA and ChpB are also anchored to the cell wall [[cite:PUB00091046]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091046":{"PMID":28783117,"ISBN":null,"volume":"7","issue":"3","year":2017,"title":"The Role of Functional Amyloids in Multicellular Growth and Development of Gram-Positive Bacteria.","URL":null,"raw_pages":null,"medline_journal":"Biomolecules","ISO_journal":"Biomolecules","authors":["Dragos A","Kovacs AT","Claessen D."],"DOI_URL":"https://doi.org/10.3390/biom7030060"},"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":23,"interactions":0,"matches":9507,"pathways":0,"proteins":6476,"proteomes":1356,"sets":0,"structural_models":{"alphafold":2903},"structures":0,"taxa":1624},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":4688},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}