{"metadata":{"accession":"PF03745","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005500","hierarchy":null,"name":{"name":"Domain of unknown function (DUF309)","short":"DUF309"},"description":[{"text":"<p>This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":4988,"pathways":0,"proteins":4982,"proteomes":4259,"sets":0,"structural_models":{"alphafold":3228},"structures":3,"taxa":6670},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":141,"alignment:full":2547},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2cwy","name":"Crystal structure of conserved hypothetical protein, TTHA0068 from Thermus thermophilus HB8"}}}