{"metadata":{"accession":"PF03724","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005184","hierarchy":null,"name":{"name":"META domain","short":"META"},"description":[{"text":"<p>Small domain family found in proteins of of unknown function. Some are secreted (e.g. [swissprot:O25998]) and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence ([swissprot:O43987]; [[cite:PUB00016654]]). A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"},"PUB00016654":{"PMID":10403759,"ISBN":null,"volume":"92","issue":"3","year":1999,"title":"Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene.","URL":null,"raw_pages":"183-91","medline_journal":"Exp Parasitol","ISO_journal":"Exp. Parasitol.","authors":["Uliana SR","Goyal N","Freymuller E","Smith DF."],"DOI_URL":"http://dx.doi.org/10.1006/expr.1999.4410"}},"set_info":{"accession":"CL0116","name":"Calycin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":94,"interactions":0,"matches":12776,"pathways":0,"proteins":11140,"proteomes":7924,"sets":1,"structural_models":{"alphafold":6968},"structures":2,"taxa":10868},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":5533},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}