Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"}},"set_info":{"accession":"CL0044","name":"Ferritin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":16107,"pathways":0,"proteins":15758,"proteomes":7077,"sets":1,"structural_models":{"alphafold":9380},"structures":11,"taxa":9875},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":7994},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2qf9","name":"Crystal structure of putative secreted protein DUF305 from Streptomyces coelicolor"}}}