{"metadata":{"accession":"PF03706","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022791","hierarchy":null,"name":{"name":"Lysylphosphatidylglycerol synthase TM region","short":"LPG_synthase_TM"},"description":[{"text":"<p>LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defensins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides [[cite:PUB00009951],[cite:PUB00109237],[cite:PUB00056129]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00009951":{"PMID":11342591,"ISBN":null,"volume":"193","issue":"9","year":2001,"title":"Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine.","URL":null,"raw_pages":"1067-76","medline_journal":"J Exp Med","ISO_journal":"J. Exp. Med.","authors":["Peschel A","Jack RW","Otto M","Collins LV","Staubitz P","Nicholson G","Kalbacher H","Nieuwenhuizen WF","Jung G","Tarkowski A","van Kessel KP","van Strijp JA."],"DOI_URL":"http://dx.doi.org/10.1084/jem.193.9.1067"},"PUB00056129":{"PMID":14769468,"ISBN":null,"volume":"231","issue":"1","year":2004,"title":"MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.","URL":null,"raw_pages":"67-71","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol. Lett.","authors":["Staubitz P","Neumann H","Schneider T","Wiedemann I","Peschel A."],"DOI_URL":"http://dx.doi.org/10.1016/S0378-1097(03)00921-2"},"PUB00109237":{"PMID":12496209,"ISBN":null,"volume":"71","issue":"1","year":2003,"title":"MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing.","URL":null,"raw_pages":"546-9","medline_journal":"Infect Immun","ISO_journal":"Infect Immun","authors":["Kristian SA","Durr M","Van Strijp JA","Neumeister B","Peschel A."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":70,"interactions":0,"matches":23283,"pathways":0,"proteins":23174,"proteomes":12135,"sets":0,"structural_models":{"alphafold":14907},"structures":6,"taxa":17771},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":49,"alignment:full":11508},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}