{"metadata":{"accession":"PF03703","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005182","hierarchy":null,"name":{"name":"Bacterial PH domain","short":"bPH_2"},"description":[{"text":"<p>Domain found in uncharacterised family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure [[cite:PUB00054230]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Pleckstrin_homology_domain","extract":"<p><b>Pleckstrin homology domain</b> or (<b>PHIP</b>) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.</p>","thumbnail":null}],"literature":{"PUB00054230":{"PMID":19913036,"ISBN":null,"volume":"396","issue":"1","year":2010,"title":"Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.","URL":null,"raw_pages":"31-46","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Xu Q","Bateman A","Finn RD","Abdubek P","Astakhova T","Axelrod HL","Bakolitsa C","Carlton D","Chen C","Chiu HJ","Chiu M","Clayton T","Das D","Deller MC","Duan L","Ellrott K","Ernst D","Farr CL","Feuerhelm J","Grant JC","Grzechnik A","Han GW","Jaroszewski L","Jin KK","Klock HE","Knuth MW","Kozbial P","Krishna SS","Kumar A","Marciano D","McMullan D","Miller MD","Morse AT","Nigoghossian E","Nopakun A","Okach L","Puckett C","Reyes R","Rife CL","Sefcovic N","Tien HJ","Trame CB","van den Bedem H","Weekes D","Wooten T","Hodgson KO","Wooley J","Elsliger MA","Deacon AM","Godzik A","Lesley SA","Wilson IA."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2009.11.006"},"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"}},"set_info":{"accession":"CL0266","name":"PH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":54,"interactions":0,"matches":35902,"pathways":0,"proteins":23024,"proteomes":9472,"sets":1,"structural_models":{"alphafold":14560},"structures":0,"taxa":14152},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":65,"alignment:full":17553},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}