{"metadata":{"accession":"PF03694","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005352","hierarchy":null,"name":{"name":"Erg28 like protein","short":"Erg28"},"description":[{"text":"<p>This is a family of integral membrane proteins, which may contain four  transmembrane helices.  Members of this family are thought to be involved  in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p  (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins [[cite:PUB00019518]].  The family contains a conserved arginine and histidine that may be  functionally important.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019518":{"PMID":11160377,"ISBN":null,"volume":"42","issue":"1","year":2001,"title":"A novel gene conserved from yeast to humans is involved in sterol biosynthesis.","URL":null,"raw_pages":"150-4","medline_journal":"J Lipid Res","ISO_journal":"J. Lipid Res.","authors":["Gachotte D","Eckstein J","Barbuch R","Hughes T","Roberts C","Bard M."],"DOI_URL":"http://www.jlr.org/cgi/content/full/42/1/150"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":47,"interactions":0,"matches":3525,"pathways":0,"proteins":3505,"proteomes":2752,"sets":0,"structural_models":{"alphafold":2990},"structures":0,"taxa":7329},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":119,"alignment:full":2649},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}