{"metadata":{"accession":"PF03668","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR053930","hierarchy":null,"name":{"name":"RapZ-like N-terminal domain","short":"RapZ-like_N"},"description":[{"text":"<p>This entry represents the N-terminal P-loop kinase domain of RNase adapter protein RapZ and related proteins. RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism [[cite:PUB00075613],[cite:PUB00150969],[cite:PUB00153826]]. It is a RNA-binding protein that recruits the major endoribonuclease RNase E to sRNAs GlmZ [[cite:PUB00075613],[cite:PUB00150969]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075613":{"PMID":23475961,"ISBN":null,"volume":"27","issue":"5","year":2013,"title":"Targeted decay of a regulatory small RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA.","URL":null,"raw_pages":"552-64","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Gopel Y","Papenfort K","Reichenbach B","Vogel J","Gorke B."],"DOI_URL":"http://dx.doi.org/10.1101/gad.210112.112"},"PUB00150969":{"PMID":28977623,"ISBN":null,"volume":"45","issue":"18","year":2017,"title":"Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.","URL":null,"raw_pages":"10845-10860","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Gonzalez GM","Durica-Mitic S","Hardwick SW","Moncrieffe MC","Resch M","Neumann P","Ficner R","Gorke B","Luisi BF."],"DOI_URL":null},"PUB00153826":{"PMID":36968430,"ISBN":null,"volume":"5","issue":"1","year":2023,"title":"New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts.","URL":null,"raw_pages":"lqad029","medline_journal":"NAR Genom Bioinform","ISO_journal":"NAR Genom Bioinform","authors":["Burroughs AM","Aravind L."],"DOI_URL":"https://doi.org/10.1093/nargab/lqad029"}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":17,"interactions":0,"matches":13329,"pathways":0,"proteins":13324,"proteomes":13052,"sets":1,"structural_models":{"alphafold":8655},"structures":6,"taxa":18078},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":6623},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9m1q","name":"Crystal structure of N-terminal domain of hypothetical protein Rv1421 from Mycobacterium tuberculosis H37Rv"}}}