{"metadata":{"accession":"PF03666","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005365","hierarchy":null,"name":{"name":"Nitrogen Permease regulator of amino acid transport activity 3","short":"NPR3"},"description":[{"text":"<p>This family, also known in yeasts as Rmd11, complexes with NPR2, [pfam:PF06218]. This complex heterodimer is responsible for inactivating TORC1. an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00053872":{"PMID":19521502,"ISBN":null,"volume":"5","issue":"6","year":2009,"title":"A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.","URL":null,"raw_pages":"e1000515","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet.","authors":["Neklesa TK","Davis RW."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pgen.1000515"}},"set_info":{"accession":"CL0435","name":"NPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":65,"interactions":0,"matches":4253,"pathways":0,"proteins":3549,"proteomes":2572,"sets":1,"structural_models":{"alphafold":2997},"structures":14,"taxa":6848},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":64,"alignment:full":3384},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}