{"metadata":{"accession":"PF03661","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005344","hierarchy":null,"name":{"name":"Transmembrane protein 33/Nucleoporin POM33","short":"TMEM33_Pom33"},"description":[{"text":"<p>This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores [[cite:PUB00075311]]. Proteins in this entry also include Tts1 from fission yeasts [[cite:PUB00075313]], Kr-h2 (krueppel homologue 2) from flies [[cite:PUB00075314]] and TMEM33 from vertebrates [[cite:PUB00085045]]. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator [[cite:PUB00075313]]. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression [[cite:PUB00075314]]. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons [[cite:PUB00085045]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075314":{"PMID":10816971,"ISBN":null,"volume":"75","issue":"2","year":2000,"title":"Kruppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila.","URL":null,"raw_pages":"137-42","medline_journal":"Genet Res","ISO_journal":"Genet. Res.","authors":["Benevolenskaya EV","Frolov MV","Birchler JA."],"DOI_URL":"http://dx.doi.org/10.1017/S0016672399004437"},"PUB00075311":{"PMID":20498018,"ISBN":null,"volume":"189","issue":"5","year":2010,"title":"Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution.","URL":null,"raw_pages":"795-811","medline_journal":"J Cell Biol","ISO_journal":"J. Cell Biol.","authors":["Chadrin A","Hess B","San Roman M","Gatti X","Lombard B","Loew D","Barral Y","Palancade B","Doye V."],"DOI_URL":"http://dx.doi.org/10.1083/jcb.200910043"},"PUB00085045":{"PMID":25612671,"ISBN":null,"volume":"60","issue":"3","year":2014,"title":"Identification and characterization of TMEM33 as a reticulon-binding protein.","URL":null,"raw_pages":"E57-65","medline_journal":"Kobe J Med Sci","ISO_journal":"Kobe J Med Sci","authors":["Urade T","Yamamoto Y","Zhang X","Ku Y","Sakisaka T."],"DOI_URL":null},"PUB00075313":{"PMID":20434336,"ISBN":null,"volume":"20","issue":"11","year":2010,"title":"The cortical ER network limits the permissive zone for actomyosin ring assembly.","URL":null,"raw_pages":"1029-34","medline_journal":"Curr Biol","ISO_journal":"Curr. Biol.","authors":["Zhang D","Vjestica A","Oliferenko S."],"DOI_URL":"http://dx.doi.org/10.1016/j.cub.2010.04.017"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":71,"interactions":0,"matches":4581,"pathways":0,"proteins":4537,"proteomes":3263,"sets":0,"structural_models":{"alphafold":3883},"structures":0,"taxa":8676},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":3438},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}