{"metadata":{"accession":"PF03658","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005346","hierarchy":null,"name":{"name":"RnfH family Ubiquitin","short":"Ub-RnfH"},"description":[{"text":"<p>A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly co-occur in two distinct gene neighborhood contexts. In one it is associated with a START domain protein, a membrane protein SmpA and the transfer mRNA binding protein SmpB. This association suggests a possible role in the SmpB-tmRNA-based tagging and degradation system of bacteria, which is interesting given that other members of the ubiquitin system are analogously involved in protein-tagging and degradation across eukaryotes and various prokaryotes. The second context in which the RnfH genes are present is in a membrane associated complex involved in transporting electrons for various reductive reactions such as nitrogen fixation [[cite:PUB00034476]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00034476":{"PMID":16859499,"ISBN":null,"volume":"7","issue":"7","year":2006,"title":"The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.","URL":null,"raw_pages":"R60","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Iyer LM","Burroughs AM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2006-7-7-r60"}},"set_info":{"accession":"CL0072","name":"Ubiquitin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":4515,"pathways":0,"proteins":4515,"proteomes":4211,"sets":1,"structural_models":{"alphafold":2916},"structures":5,"taxa":5754},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":126,"alignment:full":1909},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}