Domain is found in an undescribed set of proteins [[cite:PUB00016669]]. Normally occurs uniquely within a sequence, but is found as a tandem repeat ([swissprot:Q9X8B8]). Shows interesting phylogenetic distribution with majority of examples in bacteria and archaea, but it is also found in some fungal proteins. The hypothetical protein TT1751 from Thermus thermophilus has a beta-alpha-beta(4)-alpha structural fold [[cite:PUB00028717]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00016669":{"PMID":12625841,"ISBN":null,"volume":"3","issue":null,"year":2003,"title":"New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.","URL":null,"raw_pages":"3","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Yeats C","Bentley S","Bateman A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2180-3-3"},"PUB00028717":{"PMID":15481054,"ISBN":null,"volume":"57","issue":"4","year":2004,"title":"Crystal structure of a conserved hypothetical protein TT1751 from Thermus thermophilus HB8.","URL":null,"raw_pages":"883-7","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Kishishita S","Tatsuguchi A","Ushikoshi-Nakayama R","Terada T","Kuramitsu S","Park SY","Tame JR","Shirouzu M","Yokoyama S."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20282"}},"set_info":{"accession":"CL1004","name":"CrcB-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":8521,"pathways":0,"proteins":8300,"proteomes":5609,"sets":1,"structural_models":{"alphafold":5910},"structures":3,"taxa":9120},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":203,"alignment:full":4668},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1j3m","name":"Crystal structure of the conserved hypothetical protein TT1751 from Thermus thermophilus HB8"}}}