This family is recognised as a glycosyl-hydrolase family, number 114. It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases [[cite:PUB00066755]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Glycoside_hydrolase","extract":"In biochemistry, glycoside hydrolases are a class of enzymes which catalyze the hydrolysis of glycosidic bonds in complex sugars. They are extremely common enzymes, with roles in nature including degradation of biomass such as cellulose (cellulase), hemicellulose, and starch (amylase), in anti-bacterial defense strategies, in pathogenesis mechanisms and in normal cellular function. Together with glycosyltransferases, glycosidases form the major catalytic machinery for the synthesis and breakage of glycosidic bonds.
","thumbnail":null}],"literature":{"PUB00066755":{"PMID":21954604,"ISBN":null,"volume":"45","issue":"4","year":2011,"title":"[Endo-alpha-1-4-polygalactosaminidases and their homologues: structure and evolution].","URL":null,"raw_pages":"703-14","medline_journal":"Mol Biol (Mosk)","ISO_journal":"Mol. Biol. (Mosk.)","authors":["Naumov DG","Stepushchenko OO."],"DOI_URL":null}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":91,"interactions":0,"matches":5859,"pathways":0,"proteins":5821,"proteomes":3947,"sets":1,"structural_models":{"alphafold":3876},"structures":10,"taxa":6464},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":3637},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9ep6","name":"Alpha-Galactosaminidase family GH114 from Fusarium solani"}}}