{"metadata":{"accession":"PF03479","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005175","hierarchy":null,"name":{"name":"Plants and Prokaryotes Conserved (PCC) domain","short":"PCC"},"description":[{"text":"<p>This is a Plants and Prokaryotes Conserved (PPC) domain found in proteins that contain AT-hook motifs [pfam:PF02178] which strongly suggests a DNA-binding function for the proteins as a whole. Proteins with PPC domains are found in Bacteria, Archaea and the plant kingdom [[cite:PUB00074814],[cite:PUB00040306]].The PPC domain has a single alpha-helix packed against an antiparallel beta-sheet, which is formed by five beta-strands. There are three highly conserved histidine residues, eg at 117, 119 and 133 in [swissprot:Q46QL5] which appear to form a zinc-binding site, and the domain has been observed to form homotrimers. The domain co-occurs with a thioredoxin-like domain in uncharacterized cyanobacterial proteins [[cite:PUB00040306]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00040306":{"PMID":17295322,"ISBN":null,"volume":"67","issue":"2","year":2007,"title":"Crystal structure of Pyrococcus horikoshii PPC protein at 1.60 A resolution.","URL":null,"raw_pages":"505-7","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Lin L","Nakano H","Nakamura S","Uchiyama S","Fujimoto S","Matsunaga S","Kobayashi Y","Ohkubo T","Fukui K."],"DOI_URL":"http://dx.doi.org/10.1002/prot.21270"},"PUB00074814":{"PMID":15604740,"ISBN":null,"volume":"56","issue":"2","year":2004,"title":"Identification of a novel plant MAR DNA binding protein localized on chromosomal surfaces.","URL":null,"raw_pages":"225-39","medline_journal":"Plant Mol Biol","ISO_journal":"Plant Mol. Biol.","authors":["Fujimoto S","Matsunaga S","Yonemura M","Uchiyama S","Azuma T","Fukui K."],"DOI_URL":"http://dx.doi.org/10.1007/s11103-004-3249-5"}},"set_info":{"accession":"CL0615","name":"ALDC"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":165,"interactions":0,"matches":19300,"pathways":0,"proteins":19177,"proteomes":3910,"sets":1,"structural_models":{"alphafold":15108},"structures":7,"taxa":7806},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":235,"alignment:full":11547},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2dt4","name":"Crystal structure of Pyrococcus horikoshii a plant- and prokaryote-conserved (PPC) protein at 1.60 resolution"}}}