{"metadata":{"accession":"PF03478","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005174","hierarchy":null,"name":{"name":"KIB1-4 beta-propeller","short":"Beta-prop_KIB1-4"},"description":[{"text":"<p>This entry represents the beta-propeller domain found in F-box proteins KIB1-4, from Arabidopsis thaliana, and similar plant proteins. This domain adopts a beta-propeller structure with 6 blades and is often found in association with F-box domain ([pfam:PF00646]). KIB1-4 are ubiquitin ligases that act as essential positive regulators in brassinosteroid signalling, mediating the ubiquitination, substrate interaction and degradation of GSK3 kinase BIN2 [[cite:PUB00094297]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094297":{"PMID":28575660,"ISBN":null,"volume":"66","issue":"5","year":2017,"title":"The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.","URL":null,"raw_pages":"648-657.e4","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Zhu JY","Li Y","Cao DM","Yang H","Oh E","Bi Y","Zhu S","Wang ZY."],"DOI_URL":null}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":744,"interactions":0,"matches":32016,"pathways":0,"proteins":29927,"proteomes":382,"sets":1,"structural_models":{"alphafold":24983},"structures":0,"taxa":1130},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":79,"alignment:full":19862},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}