{"metadata":{"accession":"PF03368","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005034","hierarchy":null,"name":{"name":"Dicer dimerisation domain","short":"Dicer_dimer"},"description":[{"text":"<p>This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules.  It is essential for the activity of Dicer [[cite:PUB00067933],[cite:PUB00043694]]. It is a divergent double stranded RNA-binding domain [[cite:PUB00043692]]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [[cite:PUB00066744]]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [[cite:PUB00066744]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00067933":{"PMID":16424907,"ISBN":null,"volume":"25","issue":"3","year":2006,"title":"The role of PACT in the RNA silencing pathway.","URL":null,"raw_pages":"522-32","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Lee Y","Hur I","Park SY","Kim YK","Suh MR","Kim VN."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7600942"},"PUB00043692":{"PMID":16954143,"ISBN":null,"volume":"22","issue":"22","year":2006,"title":"DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold.","URL":null,"raw_pages":"2711-4","medline_journal":"Bioinformatics","ISO_journal":"Bioinformatics","authors":["Dlakic M."],"DOI_URL":"http://dx.doi.org/10.1093/bioinformatics/btl468"},"PUB00043694":{"PMID":17666393,"ISBN":null,"volume":"282","issue":"39","year":2007,"title":"Functional anatomy of the Drosophila microRNA-generating enzyme.","URL":null,"raw_pages":"28373-8","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Ye X","Paroo Z","Liu Q."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M705208200"},"PUB00066744":{"PMID":20106953,"ISBN":null,"volume":"16","issue":"3","year":2010,"title":"Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction.","URL":null,"raw_pages":"474-81","medline_journal":"RNA","ISO_journal":"RNA","authors":["Qin H","Chen F","Huan X","Machida S","Song J","Yuan YA."],"DOI_URL":"http://dx.doi.org/10.1261/rna.1965310"}},"set_info":{"accession":"CL0196","name":"DSRM"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":386,"interactions":0,"matches":8274,"pathways":0,"proteins":8259,"proteomes":2973,"sets":1,"structural_models":{"alphafold":1094},"structures":47,"taxa":8119},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":185,"alignment:full":5952},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}