{"metadata":{"accession":"PF03266","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004948","hierarchy":null,"name":{"name":"NTPase","short":"NTPase_1"},"description":[{"text":"<p>This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [[cite:PUB00055956]]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [[cite:PUB00032635]]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [[cite:PUB00041591]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00041591":{"PMID":17291528,"ISBN":null,"volume":"367","issue":"3","year":2007,"title":"NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase.","URL":null,"raw_pages":"788-801","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Placzek WJ","Almeida MS","Wuthrich K."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2007.01.001"},"PUB00055956":{"PMID":14503925,"ISBN":null,"volume":"4","issue":null,"year":2003,"title":"Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase.","URL":null,"raw_pages":"12","medline_journal":"BMC Biochem","ISO_journal":"BMC Biochem.","authors":["Klinger C","Rossbach M","Howe R","Kaufmann M."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2091-4-12"},"PUB00032635":{"PMID":15777481,"ISBN":null,"volume":"5","issue":null,"year":2005,"title":"Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold.","URL":null,"raw_pages":"7","medline_journal":"BMC Struct Biol","ISO_journal":"BMC Struct. Biol.","authors":["Rossbach M","Daumke O","Klinger C","Wittinghofer A","Kaufmann M."],"DOI_URL":"http://dx.doi.org/10.1186/1472-6807-5-7"}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":2897,"pathways":0,"proteins":2847,"proteomes":2218,"sets":1,"structural_models":{"alphafold":2351},"structures":2,"taxa":6361},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":2056},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1ye8","name":"Crystal Structure of THEP1 from the hyperthermophile Aquifex aeolicus"}}}