{"metadata":{"accession":"PF03159","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004859","hierarchy":null,"name":{"name":"XRN 5'-3' exonuclease N-terminus","short":"XRN_N"},"description":[{"text":"<p>This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity [ec:3.1.11.-]. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus [[cite:PUB00020569]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00020569":{"PMID":11106401,"ISBN":null,"volume":"97","issue":"25","year":2000,"title":"Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm.","URL":null,"raw_pages":"13985-90","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Kastenmayer JP","Green PJ."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.97.25.13985"},"PUB00020568":{"PMID":10349620,"ISBN":null,"volume":"79","issue":"1-2","year":1998,"title":"Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.","URL":null,"raw_pages":"51-5","medline_journal":"Mech Dev","ISO_journal":"Mech. Dev.","authors":["Till DD","Linz B","Seago JE","Elgar SJ","Marujo PE","Elias ML","Arraiano CM","McClellan JA","McCarthy JE","Newbury SF."],"DOI_URL":"http://dx.doi.org/10.1016/S0925-4773(98)00173-7"},"PUB00020567":{"PMID":8781170,"ISBN":null,"volume":"30","issue":"4","year":1996,"title":"Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability.","URL":null,"raw_pages":"284-93","medline_journal":"Curr Genet","ISO_journal":"Curr. Genet.","authors":["Szankasi P","Smith GR."],"DOI_URL":"http://dx.doi.org/10.1007/s002940050134"}},"set_info":{"accession":"CL0280","name":"PIN"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":271,"interactions":0,"matches":11038,"pathways":0,"proteins":10701,"proteomes":3313,"sets":1,"structural_models":{"alphafold":6220},"structures":19,"taxa":8706},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":123,"alignment:full":8356},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}