{"metadata":{"accession":"PF03007","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004255","hierarchy":null,"name":{"name":"Wax ester synthase/diacylglycerol acyltransferase catalytic domain","short":"WS_DGAT_cat"},"description":[{"text":"<p>This domain is found in wax ester synthases/diacylglycerol O-acyltransferases (WS/DAGs), largely found in bacteria, plants and animals. They catalyse the condensation of a fatty alcohol and a fatty acyl-Coenzyme A (acyl-CoA) and they can also catalyse the transesterification of acyl-CoAs with diacylglycerols. These are bifunctional enzymes (WS/DAGs) that share low overall sequence similarity but all WS/DGATs share a conserved HHXXXDG motif, which is also found in other acyltransferases [[cite:PUB00099698],[cite:PUB00100087]]. This entry represents the N-terminal catalytic domain of WS/DAGs which contains the conserved HHXXXDG motif. It consists of a mixed beta-sheet flanked by four alpha-helices and a small antiparallel beta-sheet [[cite:PUB00100087]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100087":{"PMID":31559109,"ISBN":null,"volume":"8","issue":"7","year":2018,"title":"Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters.","URL":null,"raw_pages":"6334-6344","medline_journal":"ACS Catal","ISO_journal":"ACS Catal","authors":["Petronikolou N","Nair SK."],"DOI_URL":null},"PUB00099698":{"PMID":12502715,"ISBN":null,"volume":"278","issue":"10","year":2003,"title":"A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1.","URL":null,"raw_pages":"8075-82","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Kalscheuer R","Steinbuchel A."],"DOI_URL":null}},"set_info":{"accession":"CL0149","name":"CoA-acyltrans"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":107,"interactions":0,"matches":15215,"pathways":0,"proteins":15050,"proteomes":4055,"sets":1,"structural_models":{"alphafold":10311},"structures":2,"taxa":6769},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":7792},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7nxg","name":"Wax synthase 1 from Acinetobacter baylyi (AbWSD1) co-crystallized with myristic acid"}}}