{"metadata":{"accession":"PF03006","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004254","hierarchy":null,"name":{"name":"Haemolysin-III related","short":"HlyIII"},"description":[{"text":"<p>Members of this family are integral membrane proteins.  This family includes a protein with hemolytic activity from Bacillus cereus [[cite:PUB00019707]]. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism [[cite:PUB00019708]]. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins [[cite:PUB00071573]]. The mammalian members include progesterone binding proteins [[cite:PUB00071574]]. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily [[cite:PUB00085069]], which are distantly related to GPCRs.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019708":{"PMID":11916977,"ISBN":null,"volume":"277","issue":"22","year":2002,"title":"Multiple regulatory roles of a novel Saccharomyces cerevisiae protein, encoded by YOL002c, in lipid and phosphate metabolism.","URL":null,"raw_pages":"19609-17","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Karpichev IV","Cornivelli L","Small GM."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M202045200"},"PUB00019707":{"PMID":7495855,"ISBN":null,"volume":"1264","issue":"2","year":1995,"title":"Cloning and primary structure of a new hemolysin gene from Bacillus cereus.","URL":null,"raw_pages":"151-4","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim. Biophys. Acta","authors":["Baida GE","Kuzmin NP."],"DOI_URL":"http://dx.doi.org/10.1016/0167-4781(95)00150-F"},"PUB00085069":{"PMID":21733186,"ISBN":null,"volume":"6","issue":null,"year":2011,"title":"CREST--a large and diverse superfamily of putative transmembrane hydrolases.","URL":null,"raw_pages":"37","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Pei J","Millay DP","Olson EN","Grishin NV."],"DOI_URL":"https://doi.org/10.1186/1745-6150-6-37"},"PUB00071573":{"PMID":16044242,"ISBN":null,"volume":"61","issue":"3","year":2005,"title":"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.","URL":null,"raw_pages":"372-80","medline_journal":"J Mol Evol","ISO_journal":"J. Mol. Evol.","authors":["Tang YT","Hu T","Arterburn M","Boyle B","Bright JM","Emtage PC","Funk WD."],"DOI_URL":"http://dx.doi.org/10.1007/s00239-004-0375-2"},"PUB00071574":{"PMID":17082257,"ISBN":null,"volume":"148","issue":"2","year":2007,"title":"Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins.","URL":null,"raw_pages":"705-18","medline_journal":"Endocrinology","ISO_journal":"Endocrinology","authors":["Thomas P","Pang Y","Dong J","Groenen P","Kelder J","de Vlieg J","Zhu Y","Tubbs C."],"DOI_URL":"http://dx.doi.org/10.1210/en.2006-0974"}},"set_info":{"accession":"CL0192","name":"GPCR_A"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":242,"interactions":0,"matches":35934,"pathways":0,"proteins":35375,"proteomes":15659,"sets":1,"structural_models":{"alphafold":27402},"structures":11,"taxa":25660},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":23760},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}