{"metadata":{"accession":"PF02958","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004119","hierarchy":null,"name":{"name":"Ecdysteroid kinase-like family","short":"EcKL"},"description":[{"text":"<p>This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates [[cite:PUB00091343]]. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterised substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes [[cite:PUB00094481]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091343":{"PMID":16899460,"ISBN":null,"volume":"281","issue":"40","year":2006,"title":"Purification, kinetic characterization, and molecular cloning of a novel enzyme, ecdysteroid 22-kinase.","URL":null,"raw_pages":"29513-24","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Sonobe H","Ohira T","Ieki K","Maeda S","Ito Y","Ajimura M","Mita K","Matsumoto H","Wilder MN."],"DOI_URL":"https://doi.org/10.1074/jbc.M604035200"},"PUB00094481":{"PMID":32540344,"ISBN":null,"volume":null,"issue":null,"year":2020,"title":"Genomic and transcriptomic analyses in Drosophila suggest that the ecdysteroid kinase-like (EcKL) gene family encodes the 'detoxification-by-phosphorylation' enzymes of insects.","URL":null,"raw_pages":"103429","medline_journal":"Insect Biochem Mol Biol","ISO_journal":"Insect Biochem. Mol. Biol.","authors":["Scanlan JL","Gledhill-Smith RS","Battlay P","Robin C."],"DOI_URL":null}},"set_info":{"accession":"CL0016","name":"PKinase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":210,"interactions":0,"matches":13042,"pathways":0,"proteins":11893,"proteomes":2359,"sets":1,"structural_models":{"alphafold":9868},"structures":0,"taxa":5457},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":51,"alignment:full":7994},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}